郭雷,男,博士,副教授,硕士研究生导师,入选连云港市第五期“521高层次人才培养工程”第三层次培养对象,省科技副总和花果山英才计划。主要从事抗菌活性物质和食品功能因子的研究。
联系方式: 15950726071 Email:leiguoo@sina.com
一、教学情况
生物制药工艺学(本科)、生物制品及药品检验(本科)、海洋生物活性物质制备工程技术(研究生)、生命科学导论(公选)
二、科研情况
(一)发表论文
1. Guo Lei*, Zhang Fei, Wang Xintong, Chen Hui, Wang Qianqian, Guo Jiacai, Cao Xi, Wang Le. Antibacterial activity and action mechanism of questin from marine Aspergillus flavipes HN4-13 against aquatic pathogen Vibrio harveyi. 3 Biotech, 2019, 9(1):14
2. Guo Lei*, Cao Xi, Yang Shulin, Wang Xintong, Wen Ying, Zhang Fei, Chen Hui, Wang Le. Characterization, solubility and antibacterial activity of inclusion complex of questin with hydroxypropyl-β-cyclodextrin. 3 Biotech, 2019, 9(4):123
3. Guo Lei*, Wang Cong. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi. 3 Biotech, 2017, 7:383
4. Guo Lei*, Guo Jiacai, Xu Fuquan. Optimized extraction process and identification of antibacterial substances from Rhubarb against aquatic pathogenic Vibrio harveyi. 3 Biotech, 2017, 7:377.
5. Guo Lei*, Wang Cong, Zhu Wencheng, Xu Fuquan. Bioassay-guided fractionation and identification of active substances from the fungus Aspergillus tubingensis against Vibrio anguillarum. Biotechnol Biotec Eq, 2016, 30(3): 602-606.
6. Guo Lei*, Guo Jiacai, Zhu Wencheng, Jiang Xinru. Optimized synchronous extraction process of tea polyphenols and polysaccharides from Huaguoshan Yunwu tea and their antioxidant activities. Food Bioprod Process, 2016, 100:303-310.
7. Wang Cong†, Guo Lei†, Hao Jiejie, Wang Liping, Zhu Weiming*. α‑Glucosidase inhibitors from the marine-derived fungus Aspergillus flavipes HN4-13. J Nat Prod, 2016, 79:2977-2981. († Co-first author)
8. Zhao Chengying†, Guo Lei†, Wang Liping, Zhu Guoliang, Zhu Weiming*. Improving the yield of (+)-terrein from the salt-tolerant Aspergillus terreus PT06-2. World J Microb Biot, 2016, 32:77. († Co-first author)
9. Guo Lei*, Zhu Wencheng, Xu Fuquan, Liu Ming, Xie Yu, Zhang Jingmin. Optimized ultrasonic-assisted extraction of polysaccharides from Cyclina sinensis and evaluation of antioxidant activities in vitro, CyTA-J Food, 2014, 12(1): 32-39.
10. Guo Lei*, Zhu Wencheng, Liu Yating, Wu Jiuyu, Zheng Anqi, Liu Yanli. Response surface optimized extraction of flavonoids from Mimenghua and its antioxidant activities in vitro, Food Sci Biotechnol, 2013, 22(5): 1285-1292.
11. Sun KL, Li Y, Guo Lei, Wang Y, Liu PP, Zhu WM*. Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei, Mar Drugs, 2014, 12(7): 3970-3981.
(二)承担科研项目
1. 江苏省高校自然科学基金项目,19KJB350007,五倍子抗哈氏弧菌效应分子群的构建及其作用机理研究,2019/09-2021/08
2. 江苏省海洋药物分子筛选重点实验室开放课题,HY201803,花蚬共生烟曲霉HX-1菌株抗水产品病原菌和特定腐败菌活性物质的研究,2019/01-2020/12
3. 江苏省海洋生物资源与环境重点实验室开放课题,CXKT20180216,水用抗菌活性化合物的发掘与应用评价,2018/01-2019/12
4. 连云港市科技项目(产业前瞻与共性关键技术),CG1612,海水养殖虾蟹育苗期弧菌病防治生物制剂开发的关键技术研究,2016/11-2018/10
5. 连云港市第五期“521工程”科研项目,海洋黄柄曲霉源大黄素-8-甲醚抗哈维氏弧菌的效应与作用机制研究,2016/12-2018/12
6. 江苏省自然科学基金面上项目,BK20151283,海洋黄柄曲霉源大黄素-8-甲醚抗水产病原哈氏弧菌的效应及作用机理研究,2015/07-2018/06
(三)成果获奖情况
1. 2018年校研究生优秀毕业论文指导教师
2. 2018年校本科优秀毕业设计(论文)指导教师
3. 2017年校大学生实践创新计划训练项目优秀指导教师
4. 2014年江苏省普通高等学校本专科优秀毕业设计(论文)指导教师
5. 2013年校本科优秀毕业设计(论文)指导教师
(四)专利情况
1. 郭雷, 陈慧, 王鑫彤, 王乐, 张菲, 曹曦, 许福泉, 陈建华. 一种花蚬共生真菌烟曲霉及其制备方法以及提取物和应用,中国,申请号:201811175359.7
2. 郭雷, 王聪, 许福泉. 利用海洋黄柄曲霉HN4-13菌株制备大黄素-8-甲醚的方法与用途,中国,专利号:ZL2015104362449
3. 郭雷, 朱文成, 许福泉, 刘玮炜, 陈丽. 塔宾曲霉SZX-6及其发酵液和发酵液提取物与用途,2014,中国,专利号:ZL2013100658863
4. 郭雷, 王淑军, 陆新龙, 陆博. 一种樱桃果酒的酿造方法,2012,中国,专利号:ZL2010105346737,转让上海巴克斯酒业有限公司,金额5.5万元。
5. 龚邦强, 郭雷, 连霁虹, 纪伟. 一种抗关节炎药物细胞靶标筛选系统及筛药的方法,2012,中国,专利号:ZL200510028953X